The salivary P.gingivalis and F. nucleatum ratios and the serum antibody titers cross-reacting with them were higher in the NASH-HCC group than in the NASH group. Additionally, F. nucleatum ratio in the saliva and the salivary IgA flow rate showed a negative correlation. Oral P. gingivalis and F. nucleatum were possibly associated with NASH-HCC pathogenesis, and salivary IgA levels were correlated with F. nucleatum. Here, CD79A is linked to hepatocellular carcinoma.