C3 and familial hyperaldosteronism: Although some degree of passive adsorption of complement proteins cannot be fully excluded, the observation that C3 deposition does not occur in HI-serum and FH cannot be detected when exposing worms to C3-depleted serum (Supplementary Figure 6) support the hypothesis that a functional connection between complement activator and regulator acquisition also applies to adult worms, albeit with less direct consequences on survival.