Upregulation of Ager which encodes the receptor for advanced glycation end-products (RAGE), leads to an unfavorable pro-inflammatory state associated with inflammatory diseases, autoimmune disorders, infections, diabetes, metabolic syndrome and its complications, obesity, insulin resistance, hypertension, atherosclerosis, neurological disorders such as Alzheimer’s disease, cardiovascular diseases, and various other conditions through multiple pathways (47–49). This evidence concerns the gene AGER and obesity due to melanocortin 4 receptor deficiency.