Transfer to Rag-/- NOD mice of activated splenocytes from Ide+/+ non-diabetic donor mice that had been depleted of B cells, CD62L+ naïve and CD25+ “regulatory” T cells (i.e. that were enriched in effector T cells) (Supplementary Figure S1), resulted in diabetes in all recipients by 4 weeks (Figure 1C). The gene discussed is SELL; the disease is diabetes mellitus.