While transfer of activated splenocytes from Ide+/+ mice alone resulted in diabetes onset at 4 weeks, reaching 90% by 7 weeks, co-transfer of “regulatory” splenocytes from both Ide+/+ and Ide-/- delayed first appearance of diabetes to 6 or 7 weeks post-infusion, 90% diabetes being reached at 11 weeks (Figure 1D). Here, IDE is linked to diabetes mellitus.