As shown in Figure 2, the expression levels of P53, NLRP3, GSDME, GSDMD, C-myc, Caspase-1, Caspase-3, Caspase-4, Bcl-2 and Bax were significantly upregulated in HNSC tumor tissues compared to normal tissues. The gene discussed is CASP4; the disease is neoplasm.