33 patients with newly diagnosed t(8;21) AML, AML1/ETO-positive (Kasumi-1, SKNO-1-PGK, and U937-A/E) and AML1/ETO-negative (SKNO-1-siA/E and U937-MT) AML cell lines. Here, RUNX1T1 is linked to acute myeloid leukemia.