Methylation pattern alteration of HMBOX1 RNA in LnCAP cells using endonuclease-dead Cas9 protein (also known as dCas9) fused to the RNA demethylase ALKBH5 or METTL3 has shown that m6A modification plays an important role in determining the tumour suppressive function of HMBOX1 (116). The gene discussed is METTL3; the disease is neoplasm.