By overlapping TCGA (The Cancer Genome Atlas)–KIRC (Kidney Clear Cell Carcinoma) up-regulated genes and RNA sequencing data from 786-O and 786-O-PR, SLC27A3 was selected based on its marked differential expression related to lipid metabolism and its crucial role in ccRCC (Fig. 1C). The gene discussed is SLC27A3; the disease is clear cell renal carcinoma.