CD4 and Guillain-Barre syndrome: It follows that the role of Th17 cells in GBS should not be overlooked, and these cells promote GBS by mediating inflammatory and autoimmune responses (19).The results of another similar study suggest that during the acute phase of the clinical course of GBS, although there is a decline in the number and proportion of CD4 + CD25+ T cells, this decline is reversible, suggesting that the number and function of Treg cells may be only temporarily suppressed rather than permanently impaired (20).