These include the development of opportunistic infections (e.g., activation of tuberculosis by TNF-α blockers), the development of a neoplasia, the de novo induction of autoimmune diseases such as systemic lupus erythematosus, the exacerbation of psoriasis or the development of (atopic dermatitis-like) eczema under biologic therapy of psoriasis [101] or bullous pemphigoid [102]. Here, TNF is linked to psoriasis.