Similarly, it was also observed that the TVGF group could individually downregulate the circadian rhythm function gene sik1 (Jagannath et al., 2013), the core gene pnp5a related to purine metabolism (Keller et al., 2022), and the gene fkbp5 (Ke et al., 2018) related to anxiety disorders mediating the recovery of stress response. Here, SIK1 is linked to anxiety disorder.