Heat shock protein family A member 8 (HSPA8) serves as a pivotal host factor in regulating Hepatitis B virus (HBV) replication and ferroptosis in liver cancer, suppressing ferroptosis by upregulating the expression of SLC7A11/GPX4 and reducing ROS and Fe2+ accumulation (Wang et al., 2023). This evidence concerns the gene HSPA8 and liver cancer.