In support, we further validated the potential functions of ACO2 co-expressed genes in these pathways using transcriptome profiles of cerebellar and retinal organoids (GSE161549 and GSE254830), reflecting the applicability of transcriptome data obtained from leukocytes to explore how ACO2 deficiency affects the neurophysiology of ICRD. The gene discussed is ACO2; the disease is infantile cerebellar-retinal degeneration.