DES and arrhythmogenic right ventricular cardiomyopathy: To date, at least 13 genes (JUP, DSP, PKP2, DSG2, DSC2, CTNNA3, TMEM43, DES, TTN, LMNA, PLN, TGFB3, and RYR2) have been identified as responsible for approximately 60% of all ARVC cases [25].