Heparin also causes the release of LPL from endothelial cells, leading to a reduction in TG levels; however, prolonged administration of heparin results in the depletion of LPL stores, decreased chylomicron catabolism, and rebound HTG.176 In a retrospective study comparing insulin and heparin treatments, insulin was found to have a greater TG-lowering effect than heparin in cases of edematous pancreatitis, with no differences in complications observed between the 2 groups.177. The gene discussed is INS; the disease is pancreatitis.