BTK and tropical spastic paraparesis: Because ATK is from a cosmopolitan Japanese isolate from a patient with ATL and our clone is from a cosmopolitan trans-continental subtype A from a HAM/TSP, we also compared the pBST sequence to the full-length genome sequence from Japanese HAM/TSP (n = 12) or Brazilian HAM/TSP (n = 10) (Supplemental S4–S12) (Figure 2D).