In addition to type I IFN, innate immune cells release pro-inflammatory cytokines and mediators, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which contribute to inflammation and the recruitment of immune cells to the site of infection, while also mediating systemic clinical signs associated with the infection. Here, IL6 is linked to infection.