A whole blood transcriptome analysis in BRSV-infected dairy calves revealed that several genes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway for Influenza A were influenced by the infection, including bovine-MHC genes (BOLA-DQ5 and BOLA-DQB), chemokines and cytokines (CXCL8, IL-12B, CXCL10), viral detection genes (DDX58 and IFIH1, which encode RIG-I and MDA5, respectively), and genes for cellular antiviral response and innate immune signaling (MX1, IRF7, EIF2AK2, RSAD2, OAS1Y, and OAS1Z) [10,129,130]. This evidence concerns the gene IFIH1 and infection.