IFNB1 and infection: In the context of poultry, miR-27b is upregulated during infection with Infectious Bursal disease virus (IBDV) and suppresses viral replication, upregulating the expression of ISGs like interferon beta (IFN-β), interferon regulatory factor 3 (IRF-3), and nuclear factor kappa beta (NF-κβ) [80,81].