RIGI and infection: Molecular studies on RIG-I-mediated sensing of certain dsDNA viruses (i.e., HSV-1 and EBV) revealed that infection induces the translocation of the 5S ribosomal RNA pseudogene 141 (RNA5SP141), a small noncoding RNA, from the nucleus to the cytoplasm, activating RIG-I and stimulating cytokine gene induction [39].