Although SARS-CoV-2 RNA was detected in most organs upon intranasal and orotracheal infection, the expression of type I, II, and III interferons was not elevated in relation to the uninfected control group, with the exception of a noticeable induction of IFNβ1 in bronchial lymph nodes upon orotracheal administration of SARS-CoV-2 (Figure 9A). This evidence concerns the gene IFNB1 and infection.