PIK3C2A and obesity due to melanocortin 4 receptor deficiency: Death, ICU admission, and the need for ventilation were found to be affected by the role of several risk factors (advanced age; diagnosis of obesity, cancer, diabetes and neuromuscular disorders; presence of abdominal pain and cough; low blood levels of oxygen saturation, platelets and albumin; and elevated blood levels of CPK, GGT, LDH, neutrophils, and elevated prothrombin time), as well as protective factors (diagnosis of hypertension and the presence of cough, sore throat, and vomiting).