The need for ventilation was found to be directly associated with low oxygen saturation (OR 5.2, IC 95% 2.8–9.4), elevated LDH (OR 3.0, IC 95% 1.5–6.3), elevated CPK (OR 2.4, IC 95% 1.5–3.7), diabetes (OR 2.3, IC 95% 1.4–3.9), neutrophilia (OR 2.2, IC 95% 1.3–3.7), obesity (OR 1.9, IC 95% 1.2–3.0), and elevated GGT (OR 1.7, IC 95% 1.1–2.7). This evidence concerns the gene PIK3C2A and obesity due to melanocortin 4 receptor deficiency.