Yet, jointly, our results strongly indicate that LRP1 plays a role in virus entry since a direct interaction of LRP1 located at the cell membrane with the virus was evidenced by means of a pull down experiment of recombinant DIII proteins with LRP1 present in microsomes of Huh-7 cells and the inhibition of infection by pre-incubation of the virus with the purified receptor. This evidence concerns the gene LRP1 and infection.