LRP1 and infection: Our results show that a synthetic peptide, obtained by structure-based design to resemble the LRP1-binding surface in DIII of the E protein and block virus–receptor interaction [72], with demonstrated inhibitory activity against DENV1–4 infection in mammalian cells, exhibits antiviral activity against DENV-1 in mosquito cells in vitro in Aag2 and c6/36 and in vivo using a vector competence assay [manuscript submitted].