CP and infection: In N. benthamiana, there also was no difference in the accumulation of either RNA or CP after infection by WT TMV vs. TMV(ORF6-); however, there was a major effect on pathogenicity: WT TMV induced a lethal systemic necrosis in infected N. benthamiana plants, whereas TMV(ORF6-) caused severe stunting with rugosity and leaf curling in infected N. benthamiana plants [43].