Third, we compared the gut and skin microbiome at enrollment of patients with IgE-mediated tree nut and/or peanut allergy (n = 15) with patients with an IgE-mediated FA other than tree nut and/or peanut (n = 8) to identify differences within different types of IgE-mediated FA. The gene discussed is IGHE; the disease is peanut allergic reaction.