Different pro-inflammatory cells accumulate in adipose tissue and secrete pro-inflammatory cytokines—interleukin 1, tumor necrosis factor, IL-6, produced by pro-inflammatory macrophages, IL-17 and interferon-gamma—produced by a subset of CD4+T cells and leptin produced by adipocytes, contributing to tissue damage and thus accelerate autoimmunity [131]. This evidence concerns the gene LEP and Autoimmunity.