In fact, the international guidelines on the topic recommend a wide range of weight loss interventions such as lifestyle modification programs (i.e., behavioral and cognitive behavioral ones) [7], as well as several anti-obesity drugs (i.e., glucagon-like peptide-1 [GLP-1] and gastric inhibitory polypeptide agonists) [8] and bariatric surgery (sleeve gastrectomy or mini gastric bypass) [9]. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.