Before CRC surgery, in comparison to individuals with a lower preoperative serum NPY concentration, patients with a serum NPY concentration higher than or equal to the median value (median; IQR: 661.70; 375.7–913.0 pg/mL) had slightly, but not clinically significantly, higher scores in the MNA, Barthel, and IADL questionnaires; were more likely to have an HGS greater than the cut-off value established for a sarcopenia diagnosis; and had (with borderline statistical significance) an SM CSA (via CT) of ≥ 92 cm2 at L3 (Table 1). The gene discussed is NPY; the disease is colorectal carcinoma.