We also found that a lower preoperative serum NPY concentration (<661.7 pg/mL) could help to identify patients with a higher percentage of weight loss before surgery (Table 1), an increased nutritional risk (NRS-2002 score ≥ 3), and a slight deterioration in their functional status at the 3-month visit after CRC surgery (Table 1, Figure 1), probably due to decreased appetite and food intake. This evidence concerns the gene NPY and colorectal carcinoma.