For instance, low-dose polyphenols in synergy with probiotics show biphasic dose-response antioxidant and anti-inflammatory activities by targeting the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and vitagenes, which improve gut bioavailability, prevent gastrointestinal diseases and inhibit the onset/progression of neurological disorders [30,31]. The gene discussed is NFE2L2; the disease is gastrointestinal disease.