Indeed, in a study with type 2 diabetes mellitus (T2DM)-afflicted obese women compared to obese women of the same age and BMI but without T2DM in the subcutaneous white adipose tissue (sWAT), the pro-inflammatory 5-LOX, DHA, AA, and the gene expression of AA positively correlated macrophage marker CD68 level was increased [86]. This evidence concerns the gene ALOX5 and type 2 diabetes mellitus.