TLR4 and metabolic dysfunction-associated steatohepatitis: Previous studies suggest that low plasma RV levels may play a role in the development of NAFLD [213]; RvD3 attenuates hepatic steatosis through AMPK signaling [214]; RvE1 modulates liver steatosis, fibrosis, and cell proliferation [215]; MaR1 has been shown to increase the polarity of liver macrophages by increasing retinoic acid-related orphan receptor α (RORα) expression and prevent the progression of NASH [216]; while RvD1 and PD1 are protective against NASH by inhibiting Toll-like receptor (TLR4) signaling [217,218].