Compared to underweight mothers, those of normal weight (β = 108.3 × 10−3, p < 0.05), overweight mothers (β = 125.0 × 10−3, p < 0.05) and those with obesity (β = 160.7 × 10−3, p < 0.05) had higher Lg αS1-CN levels in HM. Here, PTGDR is linked to obesity due to melanocortin 4 receptor deficiency.