Rs1800562 and rs1799945 in TMPRSS6 and rs1799852 in TF were the only SNPs that were found to exert a protective effect against iron deficiency in this review; however, further research, especially on rs1799945 and rs1799852, is needed to confirm their associations with iron metabolism as well as their interactions with one another and evaluate the impact of these variants on nutritional interventions. The gene discussed is TMPRSS6; the disease is Iron deficiency anemia.