The mechanisms behind IL-6 upregulation in SARS-CoV-2 involve the activation of various signaling pathways, including the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways, which amplify the inflammatory response and contribute to the severe clinical outcomes observed in COVID-19 [77]. Here, STAT3 is linked to COVID-19.