GPT and tuberculosis: Administration of an anti-TB drug mixture (INH/RIF/PZA) produced marked impairment of liver and kidney function, as shown by significant increases (p < 0.001) in serum ALP, ALT, AST, LDH, GGT, total cholesterol, triglycerides, LDL-Chol., vLDL-Chol., urea, uric acid, and creatinine levels as well as cardiac risk indices I and II (p < 0.001) in comparison to the normal control group (Table 3).