CCDC12 and colorectal cancer: The expression of curly helix domain 12(CCDC12) gene, PI3K, pAKT and mTOR genes, and proteins in HT-29 cells was decreased after the treatment of Atractylone, indicating that Atractylone can promote the apoptosis of colorectal cancer cells by inhibiting the CCDC12 and regulating the PI3K/AKT/mTOR signal pathway of HT-29.