NOTCH1 and cancer: It can activate the caspase-mediated apoptosis pathway, regulate the production of ROS, the balance of microbial flora and inflammatory factors in the gastrointestinal tract, and the EMT process to improve cell drug resistance while activating the related Notch1 pathway and downregulating PI3K/AKT/mTOR signaling pathway to mediate apoptosis and promote cell cycle arrest in different periods to induce cancer cell apoptosis, as shown in Table 1.