For aptamer No 2bi, the changes only showed a trend; however, considering its binding efficiency to the oncolytic virus, shown in this study, and to immortalized human glioblastoma cells, as shown previously [10], we also consider it a promising candidate for the development of an antitumor drug based on the recombinant virus VV-GMCSF-Lact. The gene discussed is CSF2; the disease is glioblastoma.