As the primary goal of this study was to explore the influence of different substituents in the aminoquinoline part of AMQ molecule on the inhibition of human AChE and BChE to evaluate the possibility of their use as drugs for symptomatic treatment of different stages of AD, we synthesized fourteen amodiaquine derivatives bearing H-, F-, CF3-, NO2-, CN-, CO2H- or CH3O- groups on the aminoquinoline ring. The gene discussed is ACHE; the disease is Alzheimer disease.