In line with that, AMQ derivatives with a modified quinoline ring and different 4-aminophenyl substituents exhibited additional activities important to AD’s etiology besides anti-cholinesterase activity, such as antioxidative activity and the ability to chelate Cu2+, Fe2+, Al3+ and Zn2+ ions, suggesting the potential use of AMQ-based molecules as multi-target-directed ligands (MTDLs) [19,20,30]. This evidence concerns the gene BCHE and Alzheimer disease.