MAPK8 and colorectal carcinoma: Therefore, considering previous data showing the apoptotic effect of AMTAC-19 on the HCT-116 cell line and literature data on the antitumor role of MAPKs in CRC, we present here the molecular docking prediction between AMTAC-19 and ERK1, JNK1, and p38α MAPK enzymes, as well as the in vitro effect of AMTAC-19 treatment on the modulation of these proteins and the initial redox state in human colorectal cancer cells HCT-116.