Biological evaluation of the synthesized 7-aminoalkoxy-4-aryloxy-quinazoline urea derivatives 143 concerning their inhibitory activity on VEGFR-2 and antiproliferative activity on prostate (PC-3), colorectal (HT-29), and breast (MCF-7) cancer cell lines led to the identification of compounds 143c, 143k and 143n as the most promising ones (Scheme 20D). This evidence concerns the gene KDR and cancer.