Dawood and co-workers—considering the value of the pyrazole ring in VEGFR-2 inhibition and cancer control—described the synthesis of new pyrazole hybrids, coupled with pyrazoline, thiazolopyrimidine, and pyrazolone moieties, and evaluated their biological profiles against breast cancer cells (MCF-7) (Scheme 2B,C) [16]. Here, KDR is linked to breast carcinoma.