KDR and cancer: Scheme 11B summarizes the inhibitory activities of the most promising compounds in two cancer cell lines and the VEGFR-2 enzyme. Compound 72a emerged as the most potent one, with remarkable activity against both cell lines (IC50 values of 0.22 μM and 0.42 μM for HepG2 and MCF-7, respectively). Additionally, compound 72a demonstrated the best inhibitory activity in the VEGFR-2 enzyme (IC50 of 0.067 μM) (Scheme 11B). Additional studies disclosed that compound 72a induced apoptosis in HepG2 cells, and docking simulations supported the binding interactions with the VEGFR-2 enzyme.