In contrast, the introduction of 4 ether groups (87, Figure 14) resulted in cell cycle inhibition in the G2/M phase and apoptosis in chronic lymphocytic leukemia cells (K562dox, MDR cell line with high P-gp expression; K562, CML cell line) and simultaneous activation caspase 3 and decreased parp-1 and P-gp levels. The gene discussed is PGP; the disease is B-cell chronic lymphocytic leukemia.