TP53 and neoplasm: The WTp53 tetramer identifies p53 binding sites located in the promoter or enhancer of target genes through their DNA binding domain to regulate transcription, triggering cell cycle arrest [1], senescence [2,3], apoptosis [4,5], DNA repair [1], ferroptosis [6], autophagy [7,8,9], tumor angiogenesis inhibition [10,11,12], and other functions.