Banoo, R et al. (2024) [90] report the synthesis and biological evaluation of indole-piperidine amides as multi-target-directed ligands (MTDLs) for AD, identifying 5,6-dimethoxy-indole N-(2-(1-benzylpiperidine) carboxamide (1) as a dual AChE/BACE-1 (β-secretase) inhibitor (Table 1). This evidence concerns the gene ACHE and Alzheimer disease.