TRPV1 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: It is worth mentioning that a mouse model of Dravet syndrome concluded that TRPV1 was not a viable target for the moderation of seizure activity due to the various age-dependent effects and assumed low TRPV1 expression in younger mice; however, other seizure mouse models have found higher TRPV1 expression in younger mice [72,73].