AKT1 and breast cancer: In both MCF7 and MDA-MB-231 cell lines, 10–20 μM lunasin inhibited the expression of matrix metalloproteinase (MMP)-2/-9, the phosphorylation of focal adhesion kinase (FAK), Src, Akt, ERK and nucleus translocation of NF-κB, thus demonstrating the possibility of metastasis suppression in breast cancer cells through integrin-mediated FAK/Akt/ERK and NF-κB signaling pathways and downregulation of MMP-2/-9 [108].