BCL2 and breast cancer: The cellular transformation of breast cancer is characterized by changes in signaling pathways as a result of some risk factors such as genetic and environmental that could be predisposed to it, followed by changes in molecular mechanisms accompanied by mutations in different groups of genes: tumor-suppressor genes (p53, NF1, NF2), DNA repair system genes (PTEN, BRCA1 and BRCA2 genes), oncogenes (RAS, MYC, Bcl2, RAF), and genes involved in cell growth and metabolism [12].