Mutations in Wnt proteins have not been found in the genome of breast cancer cells, but the positive regulator of their signaling Dvl is amplified in 50% of breast cancers, and the Wnt-related inhibitor Frizzled protein 1 is lost in 78% of malignant cancers diseases of the breast, which correlates with poor prognosis development of cancer [39,40]. Here, DVL1 is linked to breast cancer.