Transcriptomic and proteomic analysis of breast cancer cell line MDA-MB-231 treated with synthetic lunasin and lunasin from overexpressing transgenic maize demonstrated apoptosis activation by significant upregulation of cysteinyl aspartate specific proteinase (CASP) 3, CASP 7, and CASP 14, almost 10-fold increase in Bax/Bcl-2 ratio, and down-regulation of DNA replication genes [110,111]. This evidence concerns the gene CASP3 and breast cancer.