In preparing this review, we searched the PubMed database using the following keywords: “uveal melanoma CDK4/6 inhibitors”, “uveal melanoma CDK4 inhibitors”, “uveal melanoma CDK2 inhibitors” and “uveal melanoma CDK7/9 inhibitors” as well as similar terms for other types of melanoma and targeted kinases. The gene discussed is CDK4; the disease is uveal melanoma.