Figure 2 depicts the main processes involved in either (i) tumor elimination (represented in red) where CD8+ T cells are essential, or (ii) tumor progression (represented in blue) where Treg are the main responsible elements. In addition, coordination across lymphocytes CD8+, CD4+, Treg, NK cells, macrophages M1 and M2, MDSCs and DCs is required to regulate the development and progression of the disease. Here, CD4 is linked to neoplasm.