At this point, the QSP model reported by Ippolito et al. implements CD8/Treg and M1/M2 macrophage ratios to deal with tumor shrinkage using omics data to simulate virtual patients; meanwhile, more recently, Anbari et al. investigated potential biomarkers for uveal melanoma patients, identifying tumor and blood CD8+ T cell density, tumor CD8+/Treg ratio, and blood naïve CD4+ T cell density as key biomarkers [38,39]. The gene discussed is CD4; the disease is neoplasm.