A rather unexpected addition to the group of PHF6*-targeting peptides is hepta-histidine (7H), which was originally identified as an inhibitor of the pathological interaction between mutant Huntingtin (mHTT), a key factor in the development of Huntington’s disease (HD), and Ku70, a critical neuronal DNA damage repair protein whose function is impaired by mHTT [157,158]. The gene discussed is XRCC6; the disease is Huntington disease.