CASC3 and Miyoshi myopathy: In MM, Faict et al. [29] demonstrated that GW4869 decreased exosome secretion from 5TGM1 cells thus abrogating the inhibition of OB viability mediated by the exosomes in vitro, while the application of GW4869 combined with BTZ in a 5TGM1 mouse model decreased tumor growth and micro-vessel density, with a protective function on cortical bone volume.