MM exosomes with elevated levels of miR-27b-3p and miR-214-3p in MGUS fibroblasts were induced by transferring WWC2 protein in MM-exosomes through regulating the Hippo pathway, which prompted the proliferation and apoptosis resistance of MM fibroblasts by targeting the FBXW7 and PTEN/Akt/GSK3 pathways, respectively [36]. Here, PTEN is linked to Miyoshi myopathy.