In addition, MM-EVs could also favor extracellular environment inflammation to promote MM cell viability and migration, via stimulating BM microenvironment cells to release more cytokines, chemokines, and proteases, like IL-6, IL-8, CXCL1, matrix metallopeptidase 9 (MMP-9), and so on [16,17]. The gene discussed is MMP9; the disease is Miyoshi myopathy.