Borrolli and colleagues previously confirmed that low doses of genotoxic drugs including doxorubicin (DOX) and melphalan (MEL) induced an SASP phenotype in MM cells and the senescent MM cells could stimulate NK cells degranulating and releasing IFN-γ by up-expressing NK cell-activating ligands [53,54]. This evidence concerns the gene IFNG and Miyoshi myopathy.