For instance, a study reported that, respectively, cocultured MSCs with EVs isolated from MM cell culture supernatants and the plasma of MM patients induced MSC proliferation, while the abundant oncogenic factors (MYH4, CD166, CD44, ANXA2, and FN1, etc.)in plasma EVs could contribute to enhancing migration and adhesion [34]. Here, ANXA2 is linked to Miyoshi myopathy.