In addition to the reduction in ZnO in the nanomaterials, other parameters may have been related to the neuroprotection, all mediated by the exposure and impact of the ZnO:9Ag or ZnO:11Ag nanocomposites on experimental CD: a reduction in parasitemia, a reduction in the inflammatory infiltrate and a reduction in intestinal TNF-α. Here, TNF is linked to parasitic infectious disease.