Selected derivatives have been shown to degrade AR/AR-V7 and Mnk1/2 (mitogen-activated protein kinases 1 and 2), and then block human PC cell proliferation, induce apoptosis, inhibit cell migration, etc. Additionally, galeterone and its analogs (alone or in combination) reduced the growth of human PC cell lines resistant to certain antineoplastic drugs. The gene discussed is AR; the disease is pachyonychia congenita.