Guo et al. [22] showed that the use of linsitinib and acetylsalicylic acid (ASA) as IGF1-R antagonists inhibited the resistance of colon cancer to regorafenib, the growth of colon-cancer-like stem cells, decreased the expression of CD133, CD44, and CD24 genes, and increased the expression of CDX2 and PTEN genes. This evidence concerns the gene CD44 and malignant colon neoplasm.