The objective of this study was to prepare and preclinically evaluate [99mTc]Tc-iPSMA-Bombesin ([99mTc]Tc-iPSMA-BN), estimate dosimetry in healthy subjects, and assess the diagnostic efficacy of the radiotracer in patients with metastatic PC, with the hypothesis of non-inferiority to one of the gold standards, [18F]-PSMA-1007. Here, GRP is linked to pachyonychia congenita.